PD Peritonitis and the Gut Microbiome

Researchers investigated a causal relationship between the gut microbiome and peritonitisby combining Mendelian randomization of statistics from genome-wide association studies (GWAS) and a case control study of 24 patients. The results suggested potential destabilization of the gut bacterial network in patients with peritonitis. In particular, there were significant negative correlations between interleukin-6 levels and Faecalibacterium, Coprococcus, Dorea, Anaerostipes, and Lachnospira.

Read the abstract » | (added 2025-08-21)

Tags: Mendelian Randomization, Peritoneal Dialysis associated Peritonitis, Amplicon Sequencing, Cytokine, Gut Microbiome

Black and Latino Patients: Staying on PD

Black and Latino patients are disproportionately affected by ESKD, less likely to use PD, and more likely to switch to in-center HD if they do start PD. In-depth, semistructured interviews with twelve Black and eight Latino patients who were currently or previously receiving PD found that poor mental health, medicalization of the home, and language and cultural barriers were factors in PD dropout.

Read the abstract » | (added 2025-08-21)

Tags: Ethnicity, ESKD, PD, PD Dropout

Chlorhexidine vs. Ethanol for Buttonhole AVF Disinfection

A randomized, cross-over trial compared 5mg/mL chlorhexidine in 70% ethanol vs. 70% ethanol alone in four dialysis treatments. Factors considered were arm washing, serial sampling of normal skin flora immediately before/after disinfection, and 2 and 4 hours after disinfection. Buttonhole scabs were collected and compared to each patient’s normal skin flora. Chlorhexidine was more effective than ethanol alone.

Read the abstract » | (added 2025-08-21)

Tags: Chlorhexidine, Ethanol, Skin Flora, Disinfection, AV Fistula, Buttonhole

Diabetes + PD + Self-management: Theory of Planned Behavior (TPB)

Semi-structured interviews formulated with TPB were conducted with 16 diabetic kidney disease (DKD) PD patients. Analysis identified 3 themes and 7 sub-themes related to physical and mental perception, emotions, subjective norm, continuity of care, social feedback, perceived behavioral control, and limitations on external resources. Strengthening positive feedback and social support can improve active patient participation in decision-making.

Read the abstract » | (added 2025-08-21)

Tags: Diabetic Kidney Disease, Diabetes, PD, Self management, Theory Of Planned Behavior

No Benefit to Postponing PD Catheter Removal After Transplant

Data collected from 324 patients at five centers matched patients who had PD catheters removed during transplant with those who had them removed after a transplant. Metrics included need for dialysis within 2 months after transplant, catheter-related infection/peritonitis/surgical site infection, and length of hospitalization. Analysis revealed that 14% of patients needed postoperative dialysis (no statistically significant difference between groups. There were no differences in the composite infection endpoint—but hospitalization was significantly higher in the post-transplant removal group.

Read the abstract » | (added 2025-08-21)

Tags: Catheter related Infections, Delayed Graft Function, Kidney Transplantation, Peritoneal Dialysis

U.S. PD Outcome Trends: 2009 to 2018

A USRDS analysis of data from 101,640 incident PD patients found a decrease in overall mortality from 11% (2009) to 8.4% (2018). The probability of switching to in-center HD a year after PD initiation also dropped by about 2% in patients under 75 years old.

Read the abstract » | (added 2025-07-16)

Tags: Chronic Dialysis, Incident PD , Mortality, Peritoneal Dialysis, Clinical Epidemiology

Impact of Embedded PD Catheters on Peritonitis and Mortality

Moncrief and Popovich pioneered a buried PD catheter technique (inexplicably abbreviated as SMAP). In a study, outcomes of 285 consecutive patients who had PD catheters implanted either directly (n=96) or via SMAP (n=189) were analyzed retrospectively. Both the risks of peritonitis and mortality were significantly lower in the SMAP group.

Read the abstract » | (added 2025-07-16)

Tags: Embedded PD Catheters, Peritonitis, Mortality, Moncrief And Popovich Technique

PD Outcomes Predicted by the Triglyceride-Glucose (TyG) Index

An index based on low-cost blood tests may help predict mortality, peritonitis, and technical failure on PD. Among 354 CAPD patients stratified into TyG tertiles, the highest tertile experienced significantly higher all-cause and cardiovascular death over a median of 72 months of follow-up than the lowest tertile.

Read the abstract » | (added 2025-07-16)

Tags: PD Outcomes, Triglyceride Glucose Index, Mortality, Peritonitis, CAPD

PD or HD: Which Has the Higher Risk of Infective Endocarditis (IE)?

In a retrospective analysis of 215,965 people with ESRD and more than a million age- and sex-matched people without it, IE incidence was lower in the PD group. For those doing HD, the IE incidence was lowest for those dialyzing with an AVF.

Read the abstract » | (added 2025-07-16)

Tags: ESRD, Infective Endocarditis, HD, PD

Urgent-start HD (USHD) vs. Urgent-start PD (USPD): A Meta-analysis

Compiled data from seven studies and 1,338 patients found significantly fewer complications (infectious and noninfectious) and mortality with USPD than with USHD. The authors concluded that USPD patients “could potentially function as an appropriate replacement for USHD.”

Read the abstract » | (added 2025-07-16)

Tags: Urgent start HD, Urgent start PD